Fig. 2: Thyroid differentiation score (TDS) and its association with tumor grade and gene expression. | Communications Biology

Fig. 2: Thyroid differentiation score (TDS) and its association with tumor grade and gene expression.

From: Comparative genomic and clinicopathological analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas

Fig. 2

A Heatmap of 16 thyroid metabolism and function genes used in calculating the TDS. The samples were sorted in ascending order of TDS values. The two groups T1 and T2 represent FTC and MTC tumors, respectively. B Boxplot showing the association of tumor differentiation grades [poor (n = 4), moderate (n = 16), well (n = 10)] and TDS. Transcript expression levels correlated with TDS across all 30 samples (C) and 25 FTC samples (D). The Spearman correlation coefficients were plotted against Log10 False Discovery Rate (FDR). The red circles emphasize the 16 thyroid-related genes, and the selected positively- and negatively- or anti-correlated genes are blue and green circles, respectively. E, F Boxplot of expression data where higher transcript levels were associated with high TDS (n = 12) (ADM2) and low TDS (n = 13) (KIT) within the FTC cohort.

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