Fig. 8: HIF-1α/MEK/ERK pathways in LGG-s intestinal protection.
From: Nicotine exacerbates MASH via inducing intestinal dysbiosis and barrier dysfunction
a Exploring the optimal concentration of LGG-s. b The role of LGG-s in HIF-1α-specific siRNA knockdown Caco-2 cell. c Western blot analysis for ZO-1, occludin, and claudin-1 normalized by β-actin after treatment with MEK inhibitor U0126 (n = 3). d IF staining of ZO-1. Scale bar = 200 μm. *P < 0.05, **P < 0.01, ***P < 0.001. Data are presented as mean ± SD.
