Fig. 2: The roles of KDM5C, KDM6A and KMT2B in epigenomic landscape, cell proliferation and migration. | Communications Biology

Fig. 2: The roles of KDM5C, KDM6A and KMT2B in epigenomic landscape, cell proliferation and migration.

From: Multi-omics elucidation of KDM5C, KDM6A, and KMT2B roles in cancer epigenetic dysregulation and transcriptional reprogramming

Fig. 2

a Immunoblot analyses of KDM5C and H3K4me3 in KDM5CKO cells. b Immunoblot analyses of KDM6A and H3K27me3 in KDM6AKO cells. c Immunoblot analyses of KMT2B and H3K4me3 in KMT2BKO cells. d Representative microscopic images of KDM5CKO, KDM6AKO and KMT2BKO cells. Bar: 100 μm. e–g Effect of KDM5C, KDM6A and KMT2B knockout on cell proliferation was examined by MTT assays. h Representative images and i quantification of cell migration of KDM6AKO cells. Bar: 200 μm. ****p < 0.0001.

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