Fig. 3: Loss of KDM5C, KDM6A or KMT2B induced a genome-wide changes in chromatin accessibility that correlates with transcriptomic dysregulation.

MA plot of ATAC-seq peaks comparing KDM5C^KO to WT cells (a), KDM6A^KO to WT cells (b), and KMT2B^KO to WT cells (c). The numbers of peaks with significant changes (|log₂FC| > 0.263, FDR < 0.05, redpoints) were shown. d Pie charts showed the percentage of differentially accessible ATAC-seq peaks (|log₂FC| > 0.263, FDR < 0.05) at promoter, intronic, intergenic and exonic regions. e Heat map of differentially accessible ATAC-seq peaks described in a (|log₂FC| > 0.263, FDR < 0.05) in a 5-kilobase (kb) window grouped by localization at promoter, intron and intergenic regions. f Distribution of chromatin accessibility changes associated with significantly upregulated (red) or downregulated (blue) genes comparing KDM5C^KO, KDM6A^KO, KMT2B^KO, with WT cells. p values were calculated using a two-sided Kolmogorov–Smirnov (KS) test comparing peaks associated with differentially expressed genes to all genes.