Fig. 2: Sporadic phenotypes in Dnmt3a2−/− mice.
From: Dnmt3a2 expression during embryonic development is required for phenotypic stability
A Representative image of hydronephrosis in a five-month-old Dnmt3a2−/− mouse. Note that there is no ureter connecting the right kidney with the bladder. White arrow shows normal ureter on the left side. B Representative image of hydrocephalus in a two-month-old Dnmt3a2−/− mouse. C Representative image of anophthalmia in an E15.5 Dnmt3a2−/− embryo. White dotted circle shows the hypoplastic eye on the right side. D Representative image comparing testicles from WT, Infertile, and Fertile Dnmt3a2−/− mice. E Hematoxylin and eosin staining of WT, infertile, and fertile Dnmt3a2−/− testicles. Pathology analysis reveals loss of spermatids, increase of interstitial cells (arrows), and reduced primary spermatogonia inside tubules (arrowheads), and remarkable complete loss of spermatozoa flagella in tubule lumens. Scale bar = 100 µm.
