Fig. 1: Single-cell profiling of thymic immune cells from Aire-deficient (AireC313X−/−) and wild-type (WT) mice.
From: Aire-dependent interferon signalling shapes thymocyte maturation and central tolerance in mice
a Low-dimensional (UMAP) representation of thymic immune cell populations in WT and AireC313X−/− mice, depicted in a shared UMAP space and their relative abundance per cluster. b Dotplot of conserved marker genes for the 20 thymic clusters. Size of dot represents the percentage of cells in clusters expressing a gene, while the colour represents the scaled average expression level. c UMAP plot of thymocytes after re-clustering, retaining cluster labels from the main thymus object. d Developmental trajectory graph calculated using Monocle3, coloured by pseudotime. e Boxplot depicting ordering of thymocyte clusters, based on increasing median pseudotime values.
