Fig. 2: Pathway and function enrichment analysis by IPA. | Communications Biology

Fig. 2: Pathway and function enrichment analysis by IPA.

From: Early-phase impact of obesity-associated stress on murine vascular smooth muscle cells depends on EGFR and sex

Fig. 2

A Analysis scheme. The log2FC-weighted lists of DEG served as input for the analysis to predict involved canonical pathways, upstream regulators and biofunctions as well as the direction and extend of change (z-score; activation or inhibition). B IPA results for canonical pathways using DEG of WT VSMC induced by exposure to all stressors. C The results for the canonical pathways predicted to be regulated by all stressors in at least one cell type were aligned. Presented pathways were filtered for z-score > 2 or < −2 and B-H corrected p value < 0.05. The complete data sets are shown in Supplementary Data 02–05. The genes used for the different enrichment analyses are presented in Supplementary Data 18–23.

Back to article page