Fig. 9: Moderate intervention of EE did not inhibit the antitumor effects of cisplatin upon treatment in SCC-7, U-87 MG, and A549 cells. | Communications Biology

Fig. 9: Moderate intervention of EE did not inhibit the antitumor effects of cisplatin upon treatment in SCC-7, U-87 MG, and A549 cells.

From: Eleutheroside E alleviates cisplatin-induced ototoxicity by down-regulating MAPK/NF-κB/NLRP3 signaling pathway and inhibiting cochlear cell pyroptosis

Fig. 9: Moderate intervention of EE did not inhibit the antitumor effects of cisplatin upon treatment in SCC-7, U-87 MG, and A549 cells.

a, b The effect of cisplatin with different concentrations (12.5, 25, 50, 100, 200 μM) and cisplatin+EE 80 μg/mL on the viability of SCC7 cells, and cell viability was determined by the CCK-8 assay. c, d The effect of cisplatin with different concentrations (12.5, 25, 50, 100, 200 μM) and cisplatin+EE 80 μg/mL on the viability of U-87 MG cells, and cell viability was determined by the CCK-8 assay. e, f The effect of cisplatin with different concentrations (12.5, 25, 50, 100, 200 μM) and cisplatin+EE 80 μg/mL on the viability of A549 cells, and cell viability was determined by the CCK-8 assay. ****P < 0.0001, ***P < 0.001, **P < 0.01 and *P < 0.05 vs the Ctrl group. ####P < 0.0001, ###P < 0.001, ##P < 0.01 and #P < 0.05 vs the Cis group. Data are presented as mean ± s.e.m, n = 4 independent experiments.

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