Fig. 7: Signaling category between B and non-B cells in three tissues. | Communications Biology

Fig. 7: Signaling category between B and non-B cells in three tissues.

From: Single-cell analysis reveals multi-faceted features of B cell development, together with age-associated B cell subpopulations

Fig. 7: Signaling category between B and non-B cells in three tissues.The alternative text for this image may have been generated using AI.

Top 20 signaling categories for CCIs between B and non-B cells in BM (A), GC (B) and PBL (C). The top “TNF signaling category” is highlighted in red. Adhesion categories are highlighted in blue. D Signaling category overlap between three tissues. E Tumor necrosis family CCI overlap between three tissues. BM- and GC-specific CCIs are marked. F Adhesion category overlap between three tissues. All adhesion category subsets are marked. G Top 5 signaling categories across B cell subpopulations in BM. In parentheses is the number of total CCIs in a typical B cell subpopulation. The signaling category is color-coded as the legend. Notably, only a subset of signaling categories is provided in the legend to save space. For a complete list of signal categories, please refer to Figure S21. “S” in the parentheses denotes “signaling” in contrast to adhesion CCIs. Four well-known CCIs (H, FLT3L; I, CXCL12; J, IL7; K, SCF) critical for B cell development in BM predicted by CellPhoneDB as shown by the chord diagrams. Non-B cells are colored according to the lineage. Interactions are represented by ribbons linking two entities, with the one pointed by the arrow being the signal receiver.

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