Fig. 2: Biophysical characterisation of WRN binding to DNA.

a SPR data measuring the binding kinetics of a WRN to ssDNA alone and in the presence of b ATPγS, c ATP and d ADP. SPR data measuring the binding of ATPγS to WRN in the e free and f DNA-bound states. In all cases the data were fitted to a 1:1 kinetic binding model (black line).