Table 1 The possible mechanisms of mECM affecting cell behaviors
From: Mesenchymal stem cell-derived extracellular matrix for musculoskeletal tissue regeneration
Function | Involved ECM components | Involved signaling pathway |
|---|---|---|
Antioxidation | / | SIRT166 |
Anti-inflammation | / | SIRT115 |
Immunomodulation | Hyaluronic acid | CD44135 |
TGF-β1 | Integrinβ7, integrinβ9, and integrinβ114 | |
Anti-senescence | Collagen type I | SIRT153 |
Anti-osteoclastogenic property | Fibronectin | NF-κB64 |
Proliferation and maintenance of stemness | Non-collagenous proteins136 | / |
Angiogenic differentiation | Angiogenic-related cytokines137 | / |
