Fig. 4: Tissue-specific endothelial cell identities revealed by chromatin accessibility.
From: Chromatin accessibility landscapes define stromal cell identities across tissues
A UMAP visualization of endothelial cells across all tissues, with tissue distribution shown in the inset and corresponding bar plot. The heart, lung, and kidney constitute the majority of endothelial cells, respectively. B Cell density plot and identified cell clusters for endothelial cells. Liver sinusoidal endothelial cells (LSECs) were considered alongside endothelial cells from other tissues. C Genomic browser tracks showing chromatin accessibility enrichments unique to tissue-specific endothelial cells. D Gene activity scores for tissue-specific markers in endothelial cells, illustrating functional specialization. E Integration of a tissue-specific chromatin-accessible region (e.g., Masp1) with an endothelial cell marker (Flt1) in ECs to identify liver-specific endothelial cells (LSECs).
