Fig. 5: Chromatin accessibility patterns in stromal cells reflect their tissue of origin.
From: Chromatin accessibility landscapes define stromal cell identities across tissues
A UMAP of SEACells-defined metacells (n = 90) across nine tissues, with tissue types color-coded. B Tissue composition of metacells illustrated by heatmap showing the fractional contribution of each tissue to all 90 metacells. Each column represents a metacell, and each row corresponds to a tissue of origin. Color intensity reflects the proportion of cells from a given tissue within each metacell. C Annotated metacells grouped by cell type and displayed on UMAP. D Heatmap showing metacell distribution within annotated cell types. UMAP visualization of macrophages E and fibroblasts G across all tissues, with tissue distribution shown in the insets and corresponding bar plots. Tissue-specific chromatin accessibility modules identified in macrophages (F) and fibroblasts (H), visualized with heatmaps of Jaccard similarity indices. Distinct chromatin accessibility modules can be recognized on the heatmap, which significantly overlap with the metacells of a specific organ. Tissue types are color-coded on the left side of the heatmaps.
