Fig. 3: Oxtr knockdown in the SC mimics the innate defensive behavior deficit induced by LSD. | Communications Biology

Fig. 3: Oxtr knockdown in the SC mimics the innate defensive behavior deficit induced by LSD.

From: Early life adversity impairs visually evoked innate defensive behaviors via oxytocin signaling

Fig. 3: Oxtr knockdown in the SC mimics the innate defensive behavior deficit induced by LSD.The alternative text for this image may have been generated using AI.

a Schematic showing the conditional knockdown of Oxtr in the SC. b Representative images of AAV-hSyn-iCre-GFP expression (GFP, green; DAPI, blue; scale bars, 500 μm and 50 μm). c Top: Representative western blots images of OXTR levels in the SC of −/− and +/+ Oxtrflox mice; Bottom: statistical analysis of western blots (n = 4 for both −/− and +/+ groups; Student’s t test, *p < 0.05). Comparison between Oxtrflox +/+ and −/− mice of the (d) latency to refuge, e representative images of trajectories, f distance ratio, g speed (black line represents looming stimulus presentation), h mean return speed, i maximum speed, and (j) time spent in the refuge after looming (n = 30 trials from 10 mice for the −/− group, n = 36 trials from 12 mice for the +/+ group; Mann-Whitney U-test, **p < 0.01, ***p < 0.001).

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