Fig. 5: Phylogenetic structure and protein covariance of P2-like viruses (P2Vs). | Communications Biology

Fig. 5: Phylogenetic structure and protein covariance of P2-like viruses (P2Vs).

From: Global genomic diversity of temperate P2-like viruses

Fig. 5: Phylogenetic structure and protein covariance of P2-like viruses (P2Vs).The alternative text for this image may have been generated using AI.

A Maximum-likelihood phylogenetic tree of 5,945 P2Vs constructed from concatenated hallmark proteins using IQ-TREE2 (model: Q.pfam+F + R 10). From outer to inner, concentric rings represent: viral clusters (SpCs), environmental origin and predicted host order. Node styles denote sequence types: isolates (green dots), proviruses (red lines), and UViGs (navy lines). B Co-variation analysis of hallmark proteins at the amino acid level using mfDCA. Protein pairs in the top 1% of co-variation scores are shown; those exceeding control thresholds are considered significantly co-variable. Negative controls: Lambdavirus integrase–terminase; positive controls: portal–terminase. Statistical significance was assessed by t-test.

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