Fig. 2: Intrinsic properties of CA1 pyramidal neurons in young anesthetized APP/PS1 mice in vivo. | Communications Biology

Fig. 2: Intrinsic properties of CA1 pyramidal neurons in young anesthetized APP/PS1 mice in vivo.

From: Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer’s disease in vivo

Fig. 2: Intrinsic properties of CA1 pyramidal neurons in young anesthetized APP/PS1 mice in vivo.The alternative text for this image may have been generated using AI.

Representative in vivo current-clamp recording traces from CA1 pyramidal neurons in WT (A) and APP/PS1 (B) mice in response to injected stepwise current injections. C Input-frequency relationship showing action potential frequency as a function of injected current. No significant difference was detected between genotypes. D–I Quantification of intrinsic membrane and action potential properties. D Resting membrane potential was comparable between groups. E Input resistance did not differ significantly between genotypes. F The action potential threshold remained unchanged. G Action potential peak amplitude was similar between WT and APP/PS1 mice. H The maximum action potential rise speed was not significantly different. I Action potential half-width was decreased in APP/PS1 mice compared to WT (P = 0.049), suggesting altered spike kinetics. Data are presented as mean ± SEM in bar graphs with individual values in dots. Asterisks indicate statistical significance (*P < 0.05).

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