Fig. 4: Altered oscillation-associated synaptic currents in anesthetized young APP/PS1 mice. | Communications Biology

Fig. 4: Altered oscillation-associated synaptic currents in anesthetized young APP/PS1 mice.

From: Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer’s disease in vivo

Fig. 4: Altered oscillation-associated synaptic currents in anesthetized young APP/PS1 mice.The alternative text for this image may have been generated using AI.

A Left: Representative oscillation-associated excitatory postsynaptic currents (EPSCs) recorded in WT and APP/PS1 mice. Right: Normalized power spectral density of oscillation-associated EPSCs (0.1–100 Hz) in WT (blue) and APP/PS1 mice (red), respectively. Thick line represents the mean, and shading represents SEM. Insets show zoomed-in power spectrum (0.1–25 Hz). B Same as in (A), but for oscillation-associated inhibitory postsynaptic currents (IPSCs). Quantification of total EPSC power (C), and normalized EPSC power in slow wave (D), delta (E), theta (F), Beta (G), and gamma (H), respectively. APP/PS1 mice exhibited significantly reduced slow wave power (P = 0.038), but increased theta (P = 0.017) and beta power (P = 0.019), indicating a shift of oscillation-associated excitatory synaptic input towards faster dynamics. I, J Quantification of theta/delta and theta + beta/slow + delta ratio. APP/PS1 mice showed a significantly elevated theta/delta ratio (P = 0.028) and composite theta + beta/slow + delta ratio (P = 0.006). K–R Same analysis as in (C–J) but for oscillation-associated IPSCs. Data are presented as mean ± SEM in bar graphs with individual values in dots. Asterisks indicate statistical significance (*P < 0.05, **P < 0.01).

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