Fig. 6
From: Confinement and substrate topography control cell migration in a 3D computational model
Effect of Gaussian curvature on cell spreading and motility. A ‘sphere-with-skirt’ surface was studied as recently suggested26. a On the top, where cG > 0, a cell can spread but will not move if perturbed. b On the ‘skirt’, where cG < 0, cells are repelled, i.e., polarize and move away from the structure. c In fact, as in experiments, cells prefer the region in between, where they can easily spread and circle around the structure
