Fig. 3: Vascular damage in brain and cervical spinal cord at clinical onset. | Communications Physics

Fig. 3: Vascular damage in brain and cervical spinal cord at clinical onset.

From: Multilevel X-ray imaging approach to assess the sequential evolution of multi-organ damage in multiple sclerosis

Fig. 3

X-ray phase contrast tomography (XPCT) shows vascular damage in experimental autoimmune encephalomyelitis (EAE) brain and cervical spinal cord at clinical onset. a XPCT image showing a representative sagittal view of cerebellum, brain stem, and cervical spinal cord of an EAE-induced mouse at disease onset. The yellow and green squares indicate respectively where the lesions showed in (b) and (c) are located. Scale bar = 500 μm. b XPCT image of a detail of the brainstem at EAE onset, with the presence of clouds (indicated by the yellow arrow) at the base of the vessels (scale bar = 50 μm). c XPCT image showing coronal view of the cervical spinal cord of an EAE-induced mouse at onset. Green arrows highlight the vascular lesions (scale bar = 150 μm). Clinical EAE score at the onset = 1.5. Images were obtained as maximum intensity projections of XPCT volumes (a over 150 μm; b over 80 μm; c over 100 μm). XPCT images were acquired in Experiment 3, reported in Methods.

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