Extended Data Fig. 9: Oncogenic processes associated with the imaging subtypes in three cancer types.
From: Radiological tumour classification across imaging modality and histology
Oncogenic processes associated with the imaging subtypes in three cancer types. Limma-modeled enrichment analysis by single-sample Gene Set Enrichment Analysis (ssGSEA) of 50 cancer hallmark pathways is applied. Volcano plot of enrichment scores in lung cancer: a) subtype 1 versus rest, and b) subtype 4 versus rest; in breast cancer: c) subtype 1 versus rest, and d) subtype 4 versus rest; in GBM: e) subtype 1 versus rest, and f) subtype 4 versus rest. The enrichment scores of 50 cancer hallmark pathways are plotted as log2 fold change versus the −log10 of the adjusted p-value. Thresholds are shown as dashed lines. Pathways deemed as significantly different (false discovery rate [FDR] < 0.05) are highlighted with different color schemes.
