Table 2 The comparison of causal variable determination for the PORTEC dataset among ICP, NICP and the proposed method
From: Automated causal inference in application to randomized controlled clinical trials
Proposed (warm-up) | Proposed (complete) | |||||
|---|---|---|---|---|---|---|
Causal prob. | HR (95% CI) | P value | Causal prob. | HR (95% CI) | P value | |
Hazard analysis of P | ||||||
Pathological | ||||||
Myometrial invasion | 55.33% | 1.21 (1.17–1.25) | 0 | 52.13% | 1.26 (1.21–1.31) | 0 |
Grade | 62.72% | 1.45 (1.36–1.55) | 0 | 60.71% | 1.62 (1.51–1.74) | 0 |
LVSI | 60.68% | 1.33 (1.26–1.41) | 0 | 59.41% | 1.48 (1.39–1.57) | 0 |
Sanity check | ||||||
Tissue area | 49.31% | 0.93 (0.92–0.95) | 2.01 × 10–9 | 35.96% | NA | NA |
Patient ID | 50.93% | 0.97 (0.96–0.98) | 6.05 × 10–16 | 20.61% | NA | NA |
Hazard analysis of PM | ||||||
Pathological | ||||||
Myometrial invasion | 54.62% | 1.34 (1.29–1.39) | 0 | 53.16% | 1.43 (1.39–1.48) | 0 |
Grade | 60.44% | 2.08 (1.95–2.21) | 0 | 60.42% | 2.46 (2.33–2.59) | 0 |
LVSI | 62.13% | 2.01 (1.87–2.16) | 0 | 60.87% | 2.44 (2.30–2.60) | 0 |
Molecular | ||||||
L1CAM | 60.27% | 2.00 (1.88–2.12) | 0 | 60.43% | 2.33 (2.21–2.45) | 0 |
POLEmut | 49.91% | 0.94 (0.93–0.96) | 4.68 × 10–10 | 50.02% | 0.94 (0.92–0.95) | 1.08 × 10–12 |
MMRd | 49.20% | 0.99 (0.98–1.00) | 0.18 | 49.25% | 0.99 (0.98–1.01) | 0.31 |
p53abn | 64.67% | 2.61 (2.41–2.84) | 0 | 63.92% | 3.22 (3.00–3.46) | 0 |
Sanity check | ||||||
Tissue area | 49.77% | 0.89 (0.88–0.91) | 0 | 24.94% | NA | NA |
Patient ID | 48.98% | 0.92 (0.91–0.94) | 0 | 17.48% | NA | NA |
Hazard analysis of PMI | ||||||
Pathological | ||||||
Myometrial invasion | 55.22% | 1.40 (1.34–1.45) | 0 | 53.84% | 1.46 (1.41–1.52) | 0 |
Grade | 59.39% | 1.97 (1.87–2.08) | 0 | 59.74% | 2.22 (2.11–2.34) | 0 |
LVSI | 61.88% | 2.04 (1.89–2.19) | 0 | 60.56% | 2.35 (2.20–2.51) | 0 |
Molecular | ||||||
L1CAM | 59.91% | 1.97 (1.87–2.08) | 0 | 59.92% | 2.16 (2.06–2.26) | 0 |
POLEmut | 50.08% | 0.89 (0.88–0.91) | 0 | 50.46% | 0.89 (0.88–0.91) | 0 |
MMRd | 49.10% | 1.02 (1.01–1.04) | 0.0004 | 49.40% | 1.05 (1.04–1.07) | 6.90 × 10–12 |
p53abn | 63.82% | 2.65 (2.44–2.87) | 0 | 62.91% | 3.01 (2.80–3.22) | 0 |
Immune | ||||||
CD8+ cell density | 56.33% | 0.64 (0.61–0.66) | 0 | 56.14% | 0.59 (0.57–0.61) | 0 |
Sanity check | ||||||
Tissue area | 49.58% | 0.90 (0.88–0.92) | 0 | 21.12% | NA | NA |
Patient ID | 49.18% | 0.92 (0.91–0.94) | 0 | 22.89% | NA | NA |
