Extended Data Fig. 3: A participant shows sudden OA progression within two years.
From: Image prediction of disease progression for osteoarthritis by style-based manifold extrapolation
(a) This OAI participant (male, 51 years old) exhibited accelerated knee OA between six- and eight-year follow-ups. This sudden OA onset can be seen in the final 8-year visit radiograph indicated by the red arrows in the 1st row of (a). The 2nd row visualizes the images as predicted by our model. Progression towards OA was correctly predicted between 4 to 8 years of synthesized follow-ups generated by our method, yet not at the same rate as the true progression. (b) The proposed OA risk curves between real visits and generated predictions. The real curve in blue colour precisely captured the rapid OA onset within this participant. A quantitative evaluation of our predictions (red curve) shows a moderate OA increase that is slower than the true course.
