Extended Data Fig. 8: GO Biological Process FDRs for signaling pathways.
From: Hypergraph factorization for multi-tissue gene expression imputation
GO Biological Process enrichment analysis of metagene factors. For every pathway and factor, we selected the metagene with lowest FDR and depicted statistically significant values (FDR < 0.05). Point sizes are inversely proportional to the FDR values. Type I interferons (IFNs), a family of cytokines that activate a variety of signaling cascades, were the most enriched. We also detected the simultaneous enrichment of interferon IRF1 and STAT1 (a member of the STAT protein family that drives the expression of many target genes) in 10 factors (FDR < 0.05; Extended Data Figure 6b), consistent with these results.
