Extended Data Fig. 6: Comprehensive survival analysis by combining BRAF mutation and the predicted cell class proportions of clinical melanoma samples.

a, Distribution of predicted cell class proportions of melanoma samples grouped by BRAF mutation (n = 90 melanoma samples for BRAF non-mutation group; n = 64 melanoma samples for BRAF mutation group). Boxplots show the median (center lines), interquartile range (hinges), and 1.5 times the interquartile range (whiskers). b, Forest plot showing the hazard ratios and 95% confidence intervals of BRAF mutation, vertical growth melanoma and radial growth melanoma in melanoma patients. Black squares represent the hazard ratios, and the horizontal bars extend from the lower limit to the upper limit of the 95% confidence interval of the estimate of the hazard ratio. The P value was computed using a two-sided log-rank test. c, Kaplan–Meier plot of the predicted proportions (above and below median) of vertical growth melanoma for melanoma samples without BRAF mutation. The P value was computed using a two-sided log-rank test. d, Kaplan–Meier plot of the predicted proportions (above and below median) of radial growth melanoma for melanoma samples without BRAF mutation. The P value was computed using a two-sided log-rank test. e, Kaplan–Meier plot of the predicted proportions (above and below median) of vertical growth melanoma for melanoma samples with BRAF mutation. The P value was computed using a two-sided log-rank test. f, Kaplan–Meier plot of the predicted proportions (above and below median) of radial growth melanoma for melanoma samples with BRAF mutation. The P value was computed using a two-sided log-rank test.