Extended Data Fig. 3: Analysis of mitochondrial DNA (mtDNA) mutations detected in individual small intestinal adenomas from PolgAmut/mut;Apcfl/fl and Apcfl/fl mice. | Nature Cancer

Extended Data Fig. 3: Analysis of mitochondrial DNA (mtDNA) mutations detected in individual small intestinal adenomas from PolgAmut/mut;Apcfl/fl and Apcfl/fl mice.

From: Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis

Extended Data Fig. 3

a: The frequency of heteroplasmic variants >3% detected in adenomas from PolgAmut/mut;Apcfl/fl (n = 3 mice per group and n = 10 adenomas per mouse) and Apcfl/fl mice (n = 3 mice per group, n = 5 adenomas per mouse), mean ±s.d. are shown. b–d: Analysis of mtDNA variants present at >30% heteroplasmy in individual adenomas from PolgAmut/mut;Apcfl/fl mice (n = 413 mtDNA mutations in total). For location (b), expected values were calculated based on the proportion of the mitochondrial genome taken up by each gene category and observed and expected values compared using Chi-squared analysis. No significant deviation from the expected frequencies was detected (P = 0.4744).

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