Extended Data Fig. 3: Schematic of the fatty acid metabolism. | Nature Cancer

Extended Data Fig. 3: Schematic of the fatty acid metabolism.

From: Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase

Extended Data Fig. 3

Glucose or glutamine-derived citrate or free Acetyl-CoA serve as precursor for saturated fatty acid, further un-saturated to provide either triglycerides or phospholipids. Saturated fatty acids can also enter cycle of degradation within the mitochondrion through beta-oxidation. ACLY: ATP- Citrate Lyase; FASN: Fatty Acid Synthase; SCD: Stearoyl-CoA Desaturase; ACC: Acetyl CoA Carboxylase; CPT: Carnitine Palmitoyltransferase; HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase; SQLE: Squalene epoxidase; TCA: Tricarboxylic acid cycle; FA: Fatty acid; FAO: Fatty acid oxidation.

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