Extended Data Fig. 5: KrasG12D locks in PDLP-associated chromatin changes. | Nature Cancer

Extended Data Fig. 5: KrasG12D locks in PDLP-associated chromatin changes.

From: Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer

Extended Data Fig. 5

a, Additional ATAC-seq tracks of key KrasG12D-regulated genes. b, ATAC-seq signal intensity at the PDLP-derived K-LOCKEDOPEN sites in the indicated samples. P-values obtained by a Kolmogorov–Smirnov test, two sided. ****, p<1x10-5. c, ATAC-seq tracks showing PDLP-linked chromatin closing at K-LOCKEDDOWN genes. d, ATAC-seq signal intensity at the PDLP-derived K-LOCKEDCLOSED sites in the indicated samples. P-values obtained by a Kolmogorov–Smirnov test, two sided. ****, p<1x10-5, ***, p<.001, **, p<.01. e, Peak heatmap of K-LOCKEDCLOSED regions throughout the course of inflammation.

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