Extended Data Fig. 6: Human ADM is readily identified using scATAC-seq. | Nature Cancer

Extended Data Fig. 6: Human ADM is readily identified using scATAC-seq.

From: Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer

Extended Data Fig. 6: Human ADM is readily identified using scATAC-seq.The alternative text for this image may have been generated using AI.

a, H&E sections of patient samples used for scATAC-seq. Scale bars, 100um. b, Aggregate scATAC-seq tracks depicting chromatin opening at the ductal marker gene KRT19 and the acinar marker PTF1A. Subpopulations correspond to those indicated in Fig. 3f, lower panel. c, Aggregate scATAC-seq tracks depicting aggregate chromatin opening at K-LOCKEDCLOSED genes in the cancer and normal ductal subpopulations. d, Tracks depicting scATAC-seq chromatin opening at the K-LOCKEDCLOSED gene FOXJ1 in the human ADM subpopulation compared with cancer and normal ductal cells.

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