Extended Data Fig. 1: A Klf5 knock in mouse allows isolation of pancreatic ductal cells. | Nature Cancer

Extended Data Fig. 1: A Klf5 knock in mouse allows isolation of pancreatic ductal cells.

From: Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer

Extended Data Fig. 1

a, Expression of reported ductal TFs in TCGA PDA RNA-seq data. b, Ductal TF expression in PDA tumors (n=179) compared to normal pancreas (n=171) from GEPIA58. c, Immunofluorescence for mCherry, Klf5, and Krt19 in the healthy pancreas, or in the inflamed pancreas of a CAE-treated mouse. For each condition, two fields of view (FOV) are shown, representative of three mice for each condition. Enlarged images of an mCherrypos normal duct in the healthy pancreas and an mCherrypos ADM lesion in the inflamed pancreas are included as insets. Scale bars, 50um. d, IHC for Klf5 performed in the same conditions as (c) in the healthy pancreas (n=3), or in the inflamed pancreas (n=2), scale bars, 50um.

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