Extended Data Fig. 8: Activity of dasatinib sensitivity-related genes across normal T cell developmental stages in mouse and human.
a,b, The activity of dasatinib sensitivity-related genes vary by T cell differentiation stage in mouse. RNA-based gene expression profile was obtained from the previously published dataset (Mingueneau et al. 2013), and NetBID was used to infer gene activity. a, NetBID-inferred activity of the 30 biomarker genes. Each mouse T cell developmental stage is represented as a column and each row indicates different genes in the biomarker panel. Gene activity is represented by color (low to high as blue to red). b, NetBID-inferred activity of PTCRA and LCK. Horizontal bars indicate the mean of gene activity for each T cell population. DN3-4 stages are highlighted in red. c–e, NetBID-inferred dasatinib biomarker score and activity of PTCRA and LCK in 10 normal human T cell developmental stages. RNA-based gene expression profile of human T cells was obtained from the previously published dataset (Casero et al. 2015). NetBID was used to infer LCK (d) and PTCRA (e) activity and biomarker score (c). Thy3 and Thy4 (approximately equivalent to DN3-4 and DN4 stages in mouse) are highlighted in red.
