Extended Data Fig. 10: Comparison of human HCC cells and weight development of tumor bearing mice.
From: LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
a, Representative western blot analysis of Nrf2, Akt-1 and LXRα in different human HCC cells (cropped blot images, n = 3 independent experiments). β-actin was used as a loading control. b, LXRE reporter assay in different human HCC cells upon lentiviral infection of pL-LXRE-GFP (GFP measurements in individual cells; values represent mean ± SD, n = 5 independent experiments, statistical significance was calculated using two-tailed Student´s t test). c, Weight development of CB17.Cg-PrkdcscidLystbg/Crl mice upon subcapsular injection of HuH7 cells into the liver and treatment with T0901317/sorafenib or carrier (values represent mean ± SD, n = 6 mice per group statistical significance was calculated using two-tailed Student´s t test). Unprocessed images of the blots and numerical source data are provided as source data files.
