Extended Data Fig. 5: Rearrangement signatures extracted per organ from 3107 samples, part 1.

First part of 116 organ-specific substitution signatures, obtained across 19 organs (n = 3021 samples). Signatures names have letters or numbers (between parentheses), where numbers indicate the associated reference signatures as defined by the conversion matrix (Methods and Supplementary Table 10). Detailed data for the analyses shown in this figure can be found in Supplementary Table 3 and 113.