Extended Data Fig. 7: Hierarchical clustering of substitution mutational signatures obtained from organ-wise independent extraction.

a, Clustering of organ-wise extracted substitution signatures, using hierarchical clustering with average linkage and 1 – cosine similarity as distance metric. Red boxes indicate the identified signature groups and the corresponding group reference signature is indicated at the bottom. b, Reference signatures for each group in (a), given as the mean and standard error of the signatures in each group. Cosine similarity with the most similar COSMIC signature is indicated, along with the number of signatures in the group (n) and the reference signature name. c, Cosine similarity between the reference signature of each group and the individual signatures that belong to each group. Group sizes are the same as in panel (b). Boxes show median, 1^st and 3^rd quartile, with whiskers extending at most 1.5·IQR. Detailed data for the analyses shown in this figure can be found in Supplementary Table 2 and 4.