Extended Data Fig. 4: Pharmacokinetic analysis of BAI1.
From: A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy
a, Plasma BAI1 concentrations as a function of time following 1 mg/kg intravenous injection into adult male mice. Concentration determined by LC-MS/MS. n=3 males/time point. Data presented as mean ± s.e.m. b, Pharmacokinetic parameters estimated by non-compartmental analysis of the plasma BAI1 concentration-time curve. Kel: elimination rate constant; t1/2: half-life; Cmax: maximum plasma concentration; SE_Cmax: standard error of Cmax; Tmax: time to reach Cmax; C0: concentration at t=0; AUClast: area under the curve from t=0 to the time of the last quantifiable concentration; SE_AUClast: standard error of AUClast; AUCinf: AUC from t=0 to infinity; AUCextrap: extrapolated AUC from last to infinity, expressed as percentage of AUCinf; Vz: volume of distribution following administration; Cl: total body clearance following administration, calculated from dose/AUC; AUMCinf: area under the first moment curve from t=0 to infinity; MRTinf: mean residence time, calculated by dividing the AUMCinf by the AUC; Vss: steady-state volume of distribution, calculated from Cl · MRTinf.
