Extended Data Fig. 10: BAI1 does not attenuate doxorubicin-induced killing of human cancer cells.
From: A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy
a, b, BAI1 alone does not affect cell viability of various cancer cell lines. Cellular viability measured by maintenance of plasma membrane integrity (CytoTox-Glo). c, d, BAI1 does not interfere with the ability of doxorubicin to kill these cells. For panels c and d, untreated cells (no doxorubicin and no BAI1) assigned a viability of 100% (not shown). All panels, n=3 independent experiments. One-way ANOVA, compared with BAI1 0 µM, ** P=0.0091. All data presented as mean ± s.e.m. For comparison, BAI1 at nanomolar concentrations inhibit cardiomyocyte death (Fig. 4).
