Extended Data Fig. 7: Kaplan-Meier survival curves and unadjusted two-sided logrank test p-values for H3K27me3 within age and EZH2 strata, and EZH2 within age and H3K27me3 strata, scored by immunohistochemistry, for ER+ cases. | Nature Cancer

Extended Data Fig. 7: Kaplan-Meier survival curves and unadjusted two-sided logrank test p-values for H3K27me3 within age and EZH2 strata, and EZH2 within age and H3K27me3 strata, scored by immunohistochemistry, for ER+ cases.

From: Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects

Extended Data Fig. 7

The two left columns show ER positive cases’ survival curves for H3K27me3 low (< 60% tumour cells positively stained) versus H3K27me3 high (60% or more tumour cells positively stained) within age (rows) and EZH2 (columns) strata (Big Series TMA, N = 3991 total cases). The cohort sizes N for H3K27me3 low, and H3K27me3 high respectively are shown above the curves. The two right columns show ER positive cases’ survival curves for EZH2 negative (< 10% tumour cells positively stained) versus EZH2 positive (10% or more tumour cells positively stained) within age (rows) and H3K27me3 (columns) strata. The cohort sizes N for EZH2 negative, and EZH2 positive respectively are shown above the curves. The youngest cases show a marked difference in survival between H3K27me3 low and high cohorts within the EZH2 negative strata, while the oldest cases do not show a marked difference in the EZH2 positive strata. (See Extended Data Fig. 8 for ER- cases).

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