Extended Data Fig. 9: Kaplan-Meier survival curves and unadjusted two-sided logrank test p-values for FOXA1 and BCL2 within age strata for ER positive cases (left two columns) and ER negative cases (right two columns). | Nature Cancer

Extended Data Fig. 9: Kaplan-Meier survival curves and unadjusted two-sided logrank test p-values for FOXA1 and BCL2 within age strata for ER positive cases (left two columns) and ER negative cases (right two columns).

From: Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects

Extended Data Fig. 9

Big Series TMA data (N = 3991 cases) survival patterns within ER and age group strata for FOXA1 and BCL2 protein staining levels. The cohort sizes N for low and high protein staining rates within each ER and age group strata are shown above the curves. For FOXA1, all survival differences occur in cases under age 55 years, specifically for 40-55 year old cases in the ER positive strata, and for 20-40 year old cases in the ER negative strata. For BCL2, survival differences are seen in the three youngest age strata for ER positive cases, but in the oldest three age strata for ER negative cases.

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