Extended Data Fig. 2: Age dependent transcript volcano plots for estrogen receptor (ER) and human epidermal growth factor receptor (HER2) subgroups for the TCGA dataset. | Nature Cancer

Extended Data Fig. 2: Age dependent transcript volcano plots for estrogen receptor (ER) and human epidermal growth factor receptor (HER2) subgroups for the TCGA dataset.

From: Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects

Extended Data Fig. 2: Age dependent transcript volcano plots for estrogen receptor (ER) and human epidermal growth factor receptor (HER2) subgroups for the TCGA dataset.The alternative text for this image may have been generated using AI.

Horizontal axis displays the maximum fold change measured from the three regression line fits to expression data from the TCGA Breast expression dataset (N = 1079 cases) for cases < 60 years of age, cases > 60, and all cases. Fold changes to the right (Up) indicate genes exhibiting an increase in expression levels from younger to older cases. Fold changes to the left (Down) indicate genes exhibiting a decrease in expression levels from younger to older cases. Genes exhibiting a large absolute fold change and strong statistical evidence of association (small p-values) appear in the upper left and right areas of the volcano plots. P-values from linear model ANOVA (2-sided F-test) based on the sample sizes shown above each plot. Genes with absolute fold change > 1.25 and adjusted p-value < 0.01 for cases age < 60 or cases age > 60 or all cases are coloured according to the legend categories for ER binding.

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