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METASTASIS

Mapping the switch that drives the pre-metastatic niche

Nature Cancer volume 1, pages 577–579 (2020)Cite this article

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The pre-metastatic niche is a complex microenvironment formed by the influence of tumor-derived factors on stromal and immune cells at distant sites of disseminated tumor-cell colonization. Signaling through the kinase p38α and regulation of the type I interferon receptor are now linked to formation of the pre-metastatic niche.

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Fig. 1: p38a signaling drives pre-metastatic niche formation.

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Authors and Affiliations

  1. Tumor Microenvironment and Metastasis Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Sabina Kaczanowska & Rosandra N. Kaplan

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  1. Sabina Kaczanowska
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  2. Rosandra N. Kaplan
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Correspondence to Rosandra N. Kaplan.

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The authors declare no competing interests.

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Kaczanowska, S., Kaplan, R.N. Mapping the switch that drives the pre-metastatic niche. Nat Cancer 1, 577–579 (2020). https://doi.org/10.1038/s43018-020-0076-9

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