Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TUMOR IMMUNOLOGY

Immunoediting of cancer metastasis by NK cells

Nature Cancer volume 1, pages 670–671 (2020)Cite this article

Subjects

Natural killer (NK) cells serve a critical role in the control of metastasis. NK cells are now shown to preferentially control monoclonal metastases derived from single circulating tumor cells rather than polyclonal metastases derived from cell clusters. These findings provide further evidence that NK cells are linked to metastatic cell immunoediting.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: NK cell immunoediting of circulating tumor cells.

References

  1. Lambert, A. W., Pattabiraman, D. R. & Weinberg, R. A. Cell 168, 670–691 (2017).

    Article  CAS  Google Scholar 

  2. López-Soto, A., Gonzalez, S., Smyth, M. J. & Galluzzi, L. Cancer Cell 32, 135–154 (2017).

    Article  Google Scholar 

  3. Schreiber, R. D., Old, L. J. & Smyth, M. J. Science 331, 1565–1570 (2011).

    Article  CAS  Google Scholar 

  4. Lo, H.C. et al. Nat. Cancer https://doi.org/10.1038/s43018-020-0068-9 (2020).

  5. Mostert, B., Sleijfer, S., Foekens, J. A. & Gratama, J. W. Cancer Treat. Rev. 35, 463–474 (2009).

    Article  CAS  Google Scholar 

  6. Cristofanilli, M. et al. N. Engl. J. Med. 351, 781–791 (2004).

    Article  CAS  Google Scholar 

  7. Cheung, K. J. et al. Proc. Natl Acad. Sci. USA 113, E854–E863 (2016).

    Article  CAS  Google Scholar 

  8. Aceto, N. et al. Cell 158, 1110–1122 (2014).

    Article  CAS  Google Scholar 

  9. Wang, C. et al. Breast Cancer Res. Treat. 161, 83–94 (2017).

    Article  Google Scholar 

  10. Raulet, D. H. Nat. Rev. Immunol. 3, 781–790 (2003).

    Article  CAS  Google Scholar 

  11. Lamouille, S., Xu, J. & Derynck, R. Nat. Rev. Mol. Cell Biol. 15, 178–196 (2014).

    Article  CAS  Google Scholar 

  12. Laughney, A. M. et al. Nat. Med. 26, 259–269 (2020).

    Article  CAS  Google Scholar 

  13. Sceneay, J., Smyth, M. J. & Möller, A. Cancer Metastasis Rev. 32, 449–464 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

    Kyohei Nakamura & Mark J. Smyth

Authors
  1. Kyohei Nakamura
    View author publications

    Search author on:PubMed Google Scholar

  2. Mark J. Smyth
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Mark J. Smyth.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nakamura, K., Smyth, M.J. Immunoediting of cancer metastasis by NK cells. Nat Cancer 1, 670–671 (2020). https://doi.org/10.1038/s43018-020-0081-z

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s43018-020-0081-z

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing