Extended Data Fig. 6: Depletion efficiency in peripheral blood (a-e) and in tumors (f). | Nature Cancer

Extended Data Fig. 6: Depletion efficiency in peripheral blood (a-e) and in tumors (f).

From: Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity

Extended Data Fig. 6

C57BL/6J mice bearing B16F10 tumors were administered the indicated depleting antibodies beginning one day prior to injection with 10 µg LNP-Rep(IL12-alb-lum). Then the depletion efficiency in peripheral blood (a-d, Untreated n = 4 mice, treated and untreated n = 5 mice/group; e, n=10 mice/group) and in tumor (f, n=5 mice/group) were determined by flow cytometer. Shown are typical FACS plots from the groups of Untreated, Treated (LNP-Rep(IL-12-alb-lum), and Treated with depleting antibodies as indicated. The mean and standard deviation of gated populations are indicated.

Source data

Back to article page