Extended Data Fig. 6: Regional heterogeneity profiled through treatment in tumor and immune markers.
Analyses based on the discovery cohort (n = 28 tumors). Heterogeneity was calculated as the mean squared error within patients based on analysis of variance. P-values are based on a two-sided Wilcoxon matched-pair signed rank test. a. Comparison of DSP CD45 protein levels pre-treatment and on-treatment for all regions profiled per case per timepoint. Also shown is a comparison of the mean squared error in DSP CD45 protein expression pre-treatment versus on-treatment within and between patients. b. Pre-, on-, and post-treatment heterogeneity for each DSP protein marker in non-pCR cases (patients with tumor cells present at surgery). c, Pre-treatment heterogeneity in DSP protein marker expression in pCR and non-pCR cases.
