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TUMOR IMMUNOLOGY

Enhancing anti-tumor immunity by autophagy inhibition

Nature Cancer volume 2, pages 484–486 (2021)Cite this article

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Two recent studies demonstrate how autophagy, in both tumor cells and host tissues, regulates anti-tumor T cell responses. These works add to accumulating evidence that inhibitors of autophagy could be used in combination with immunotherapy in certain cancer types.

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Fig. 1: Systemic inhibition of autophagy can target multiple autophagy-mediated immunosuppressive mechanisms.

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Author notes

  1. Christina G. Towers

    Present address: Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA

Authors and Affiliations

  1. Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA

    Andrew Thorburn & Christina G. Towers

Authors
  1. Andrew Thorburn
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  2. Christina G. Towers
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Corresponding authors

Correspondence to Andrew Thorburn or Christina G. Towers.

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The authors declare no competing interests.

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Thorburn, A., Towers, C.G. Enhancing anti-tumor immunity by autophagy inhibition. Nat Cancer 2, 484–486 (2021). https://doi.org/10.1038/s43018-021-00214-8

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