Extended Data Fig. 5: Associations of CLL-PD to genomic aberrations and DNA methylation.
a and b, Scatter plots showing the associations between CLL-PD and the total number of mutations detected by whole exome sequencing (a) or whole genome sequencing (b). Mutations on immunoglobulin genes were excluded when calculating the total number of mutations to avoid potential influence of somatic hypermutation. P values and coefficients were calculated by two-sided Pearson’s correlations tests. c, Associations of the CLL-PD score to genomic aberrations in the ICGC-CLL cohort (n = 249 samples). P values are from two-sided t-tests. d, Associations of the CLL-PD score to overall mutation load in the ICGC-CLL cohort. P value is from two-sided Pearson’s correlation test. e, top 10 enriched transcription factor binding motifs in the regions that show hypomethylation in samples with high CLL-PD values, P values were calculated by the Homer de novo algorithm32.
