Extended Data Fig. 6: Gene expression signatures of CLL-PD.
a to c, Heatmap plots showing the z-score of the expression values of genes that are significantly correlated with CLL-PD (1% FDR, Benjamini-Hochberg’s method) and are in the Hallmark MYC targets v1 (a), Hallmark oxidative phosphorylation (OXPHOS) (b) and Hallmark mTORC1 signaling (c) gene sets from Molecular Signatures Database (MSigDB)39. Samples (columns) are ordered by their CLL-PD values. Symbols of the genes coding mitochondrial proteins are colored in red. d, Gene enrichment analysis of genes correlated with the CLL-PD scores in the four external cohorts shown in Fig. 2b, using Hallmark gene sets from MSigDB. The names of gene sets related to MYC targets, mTOR signaling and OXPHOS are colored in red. (n = 249, 107, 130 and 81 patients for the ICGC-CLL, Munich, UCSD and Duke cohorts, respectively) e, Gene set enrichment analysis of genes correlated with CLL-PD in U-CLL (n = 107 samples) and M-CLL (n = 93 samples) separately.
