Extended Data Fig. 7: Combination of cabozantinib and nivolumab promotes systemic T cell responses. | Nature Cancer

Extended Data Fig. 7: Combination of cabozantinib and nivolumab promotes systemic T cell responses.

From: Neoadjuvant cabozantinib and nivolumab convert locally advanced hepatocellular carcinoma into resectable disease with enhanced antitumor immunity

Extended Data Fig. 7: Combination of cabozantinib and nivolumab promotes systemic T cell responses.

a, PBMCs from eight paired pre- and post-treatment samples were assayed by a 28-marker CyTOF panel dedicated to phenotyping T cells. FlowSOM algorithm was employed to generate 30 metaclusters which were then annotated into 23 final clusters. Scaled expression profile for each of the clusters are shown in the heatmap. b, Radar plot showing average fold changes for the abundance of every T cell subtype. Color legends apply to both panels A and B. P-values (edgeR) are annotated. Abbreviations: CM, central memory, DNT, double-negative T; DPT, double-positive T; Eff, effector; EM, effector memory; EX, exhaustion marker positive; N, naïve; NK, natural killer; UA, unassigned.

Source data

Back to article page