Extended Data Fig. 2: MOAlmanac investigates preclinical efficacy of nominated relationships. | Nature Cancer

Extended Data Fig. 2: MOAlmanac investigates preclinical efficacy of nominated relationships.

From: Integrating molecular profiles into clinical frameworks through the Molecular Oncology Almanac to prospectively guide precision oncology

Extended Data Fig. 2: MOAlmanac investigates preclinical efficacy of nominated relationships.The alternative text for this image may have been generated using AI.

If a nominated therapy has been characterized by the GDSC, MOAlmanac will investigate if cancer cell lines that are wild type and mutant for the associated molecular feature respond differently by comparing IC50 values using a two-sided Mann-Whitney-Wilcoxon test. For PIK3CA p.H1047R and response to Pictilisib, response data was available for 766 cancer cell lines. MOAlmanac investigated sensitivity for mutant and wild type cell lines for cell lines harboring either a PIK3CA somatic variant, copy number alteration, or fusion (n = 162 mutant cell lines, min IC50: 0.18, max: 93.92, median: 3.22, q1: 1.70, q2: 6.72; n = 604 wild type, min IC50: 0.04, max: 1616.65, median: 4.10, q1: 1.94, q3: 9.34), a PIK3CA somatic variant (n = 103 mutant cell lines, min IC50: 0.18, max: 50.01, median: 2.90, q1: 1.42, q2: 5.14; n = 653 wild type, min IC50: 0.037, max: 1616.65, median: 4.10, q1: 1.95, q3: 9.54), PIK3CA missense variants (n = 98 mutant cell lines, min IC50: 0.18, max: 50.01, median: 2.91, q1: 1.46, q2: 5.11; n = 668 wild type, min IC50: 0.037, max: 1616.65, median: 4.10, q1: 1.94, q3: 9.61), and the specific protein change PIK3CA p.H1047R (n = 21 mutant cell lines, min IC50: 0.54, max: 5.63, median: 1.86, q1: 0.865, q2: 3.25; n = 745 wild type, min IC50: 0.037, max: 1616.65, median: 3.92, q1: 1.90, q3: 9.15). Data is available as source data.

Source data

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