Extended Data Fig. 5: Abundance of Enterococcus species in feces of the subjects.
From: Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis
Copy number of E. faecalis (a, d, e), E. faecium (b), and E. casseliflavus (c) in feces of the subjects was determined by quantitative PCR. PPI-untreated subjects or subjects over 55 years old were analyzed in (d, e), respectively. n=21–24 (a-c), n=13–23 (d–f) Number of liver tumors in E. faecalis-bearing mice is shown according to presence of fecal gelE. n=13–50. (g–j) Relative abundance (%) of Bacillus (g), Staphylococcus (h), Pseudomonas (i), and Serratia (j) in feces of the mice transplanted with human feces was determined by 16SrRNA-based sequencing. n=21–24. (a–j) Means and SE are shown. (a–e and g–j) Kruskal-Wallis test. (f) two-sided Mann-Whitney U test. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Exact P-values were as follows: (a) HD vs. CLD, P=0.0007; HD vs. HCC, P=0.0002; CLD vs. HCC, P>0.999: (b) HD vs. CLD, P=0.206; HD vs. HCC, P=0.229; CLD vs. HCC, P>0.999: (c) HD vs. CLD, P>0.999; HD vs. HCC, P=0.238; CLD vs. HCC, P>0.999 (d) HD vs. CLD, P=0.0068; HD vs. HCC, P=0.0031; CLD vs. HCC, P>0.999: (e) HD vs. CLD, P=0.0014; HD vs. HCC, P=0.0019; CLD vs. HCC, P>0.999: (f) P=0.049: (g) HD vs. CLD, P>0.999; HD vs. HCC, P=0.0587; CLD vs. HCC, P=0.151: (h) HD vs. CLD, P>0.999; HD vs. HCC, P>0.999; CLD vs. HCC, P>0.999: (i) HD vs. CLD, P=0.100; HD vs. HCC, P=0.318; CLD vs. HCC, P>0.999: (j) HD vs. CLD, P>0.999; HD vs. HCC, P=0.657; CLD vs. HCC, P=0.704.
