Extended Data Fig. 8: VEN plus AraC specific residual cell clusters are phenotypically heterogeneous in vivo. | Nature Cancer

Extended Data Fig. 8: VEN plus AraC specific residual cell clusters are phenotypically heterogeneous in vivo.

From: Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia

Extended Data Fig. 8: VEN plus AraC specific residual cell clusters are phenotypically heterogeneous in vivo.The alternative text for this image may have been generated using AI.

(a–c) Visualization on the UMAP plot of hematopoietic cell signatures that best match the three VEN+AraC clusters (#6, #7, #8) using Single Cell Explorer. Cluster #6 is monocyte-like based on gene signature created from Wu et al. (Journal of Hematology & Oncology, 2020). (A); Cluster #7 is HSC like based on Van Galen gene signature (Van Galen et al. Cell, 2019). (B) and cluster #8 is Myelo-Erythroid Progenitor (MEP) like based on gene signature created from Velten et al. NCB, 2017 (C). (d) UMAP plot displaying SCENIC clusters identified based on Gene Regulatory Network inference. Colors indicate SCENIC clusters. (e) Heatmap displaying binary activity of regulons identified by SCENIC Gene regulatory network analysis.

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