Extended Data Fig. 2: Spike-reactive and neutralising antibody titers.
a) Flow cytometric assays to quantify S-reactive IgG and IgM and IgA levels in sera of patients (n = 109 for IgG and IgM, n = 51 for IgA) with S-reactive antibodies. b) S-reactive IgG, c) IgM, and d) IgA in SARS-CoV-2 positive compared with infection-naive patients (n = 40). Boxes indicate the 25 and 75 percentiles, line indicates the median, and whiskers indicate the 10th and 90th percentiles. e) Correlation between S1-reactive IgG and S1-reactive AbT in 40 patients and f) Correlation between S1-reactive IgM and S1-reactive AbT in 40 patients. Blue line denotes linear regression line with grey areas marking the 95% confidence band. Regression coefficient and p-values were computed by two-sided spearman regression, p < 0.05 was considered significant. g) S1-reactive antibodies in pre-pandemic sera of patients (n = 77). Boxes indicate the 25 and 75 percentiles, line indicates the median, and whiskers indicate the 10th and 90th percentiles. h) Correlation between NAbT against WT, Alpha, Beta, Delta and S1-reactive AbT in 112 patients. Blue line denotes linear regression line with grey areas marking the 95% confidence band. Regression coefficient and p-values were computed by two-sided spearman regression, p < 0.05 was considered significant.
